medical applications of aptamers

Aptamers and Their Biological Applications

Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocel...

Aptamers: Biomedical Interest and Applications

Aptamers are short DNA or RNA oligonucleotides specialized in the specific and efficient binding to a target molecule. They are obtained by in vitro selection or evolution processes. It was in 1990 that two independent research groups described the bases of a new in vitro technology for the identification of RNA molecules able to specifically bind to a target [1,2]. Tuerk and Gold established t...

Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery

Recent progresses in organic chemistry and molecular biology have allowed the emergence of numerous new applications of nucleic acids that markedly deviate from their natural functions. Particularly, DNA and RNA molecules-coined aptamers-can be brought to bind to specific targets with high affinity and selectivity. While aptamers are mainly applied as biosensors, diagnostic agents, tools in pro...

Smart Designed Aptamers: Applications & Effective Design Options

Nanotechnology and aptamers: applications in drug delivery.

Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics....

Applications of gold nanoparticles for medical imaging

Background & Aim: Molecular imaging enables us to non-invasively visualize tissue microstructures and lesion characterization, allowing accurate diagnosis of diseases at early stages. A successful molecular imaging requires a nontoxic contrast agent with high sensitivity. Nowadays, a wide range of nanoparticles have been developed as contrast agents for medical imaging modalities. Here, we revi...